Osman Bukari instant impact denied Angola all three points as the Black Stars secured a vital draw in Luanda to edge closer to AFCON qualification.
The Red Star Belgrade forward took less than a minute to announce his presence after connecting a cross from fellow substitute Joseph Painstil to cancel Lucas Joao's penalty for Angola.
Angola got off to a bright start with midfielder Fredy testing Ghana goalkeeper Lawrence Ati Zigi from long range.
The hosts kept Ghana at bay for most of the early exchanges with Helder Costa, Gelson and Lucas Joao causing problems for the Black Stars' defence.
Halfway through the first half, Ghana came close after a swift interplay between Mohammed Kudus and Edmund Addo left the latter with the chance of opening the scoring, but his effort went wide.
Angola threatened few minutes before the break after Costa broke off from the right only for his strike to go wide.